The Constitutive Androstane Receptor (CAR) is a nuclear receptor and functions as a sensor for xenobiotics. It regulates transcription of genes encoding proteins in metabolism and excretion of xenobiotics. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2875 CPTAC Assay Portal] b7a c91 cd2 nuclear receptor subfamily 1, group I, member 3 retinoid X receptor, alpha bdd d52 plays a role in translocation of CAR heat shock protein 90kDa alpha (cytosolic), class A member 1 nuclear receptor subfamily 1, group I, member 3 heat shock protein 90kDa alpha (cytosolic), class A member 1 retinoid X receptor, alpha nuclear receptor subfamily 1, group I, member 3 DnaJ (Hsp40) homolog, subfamily C, member 7 DnaJ (Hsp40) homolog, subfamily C, member 7 nuclear receptor coactivator 6 Sp1 transcription factor nuclear receptor coactivator 1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha nuclear receptor coactivator 2 structural maintenance of chromosomes 1A cytochrome P450, family 2, subfamily C, polypeptide 9 a2e ATP-binding cassette, sub-family B (MDR/TAP), member 1 a9d be4 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 b6a cytochrome P450, family 2, subfamily A, polypeptide 6 a9d b6a cytochrome P450, family 2, subfamily C, polypeptide 19 a2e during fasting ce9 glutathione S-transferase alpha 2 a9d cytochrome P450, family 3, subfamily A, polypeptide 5 a2e c02 cytochrome P450, family 3, subfamily A, polypeptide 4 a2e a9d b6a cytochrome P450, family 2, subfamily B, polypeptide 6 a2e ATP-binding cassette, sub-family C (CFTR/MRP), member 3 b6a a7b a7b a7b a7b df0 a9d

signaling pathway PW:0000003 Pathway Ontology 17284330 PubMed CAR and PXR: the xenobiotic-sensing receptors. Steroids 2007 Timsit YE Negishi M 12120277 PubMed PXR, CAR and drug metabolism. Nat Rev Drug Discov 2002 Willson TM Kliewer SA 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 12611900 PubMed Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 2003 Maglich JM Parks DJ Moore LB Collins JL Goodwin B Billin AN Stoltz CA Kliewer SA Lambert MH Willson TM Moore JT 15610735 PubMed A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell 2004 Xu RX Lambert MH Wisely BB Warren EN Weinert EE Waitt GM Williams JD Collins JL Moore LB Willson TM Moore JT 11803135 PubMed The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci 2002 Cai Y Konishi T Han G Campwala KH French SW Wan YJ 18288955 PubMed Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab 2008 Pavek P Dvorak Z 11343253 PubMed The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 2001 Sugatani J Kojima H Ueda A Kakizaki S Yoshinari K Gong QH Owens IS Negishi M Sueyoshi T 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA 15004031 PubMed The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem 2004 Maglich JM Watson J McMillen PJ Goodwin B Willson TM Moore JT 17595319 PubMed The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. Mol Endocrinol 2007 Echchgadda I Song CS Oh T Ahmed M De La Cruz IJ Chatterjee B 21420387 PubMed From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol 2011 Bock KW 15340055 PubMed Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol 2004 Kodama S Koike C Negishi M Yamamoto Y