PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2878 CPTAC Assay Portal] c2f ab0 ddf a4d ab0 a7b ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 ab0 b6a peroxisome proliferator-activated receptor signaling pathway PW:0001355 Pathway Ontology 15489539 PubMed PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J Lipid Res 2004 Li AC Glass CK 14999402 PubMed Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 2004 Mandard S Müller M Kersten S 16197558 PubMed Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl Recept 2005 Tachibana K Kobayashi Y Tanaka T Tagami M Sugiyama A Katayama T Ueda C Yamasaki D Ishimoto K Sumitomo M Uchiyama Y Kohro T Sakai J Hamakubo T Kodama T Doi T 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 21420387 PubMed From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol 2011 Bock KW 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA