PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2878). c2f ab0 ddf a4d b04 a7b b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b04 b6a 12120277 PubMed PXR, CAR and drug metabolism. Nat Rev Drug Discov 2002 Willson TM Kliewer SA 17952121 PubMed TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene 2008 Weiss C Faust D Schreck I Ruff A Farwerck T Melenberg A Schneider S Oesch-Bartlomowicz B Zatloukalová J Vondrácek J Oesch F Dietrich C 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA 14999402 PubMed Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 2004 Mandard S Müller M Kersten S 17266942 PubMed Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 2007 Köhle C Bock KW 17901129 PubMed Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Mol Endocrinol 2008 Gao H Fält S Sandelin A Gustafsson JA Dahlman-Wright K 15496506 PubMed 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin. Mol Pharmacol 2005 Marchand A Tomkiewicz C Marchandeau JP Boitier E Barouki R Garlatti M 21908933 PubMed 21908933 PubMed Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]. Endocr J 2011 21908933 PubMed Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]. Endocr J 2011 21908933 PubMed Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]. Endocr J 2011 Hashimoto K Mori M 14999402 PubMed Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 2004 Mandard S Müller M Kersten S 9099515 PubMed Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997 Rowlands JC Gustafsson JA 15489539 PubMed 15489539 PubMed PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J Lipid Res 2004 Li AC Glass CK 18848820 PubMed Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem Pharmacol 2009 Haarmann-Stemmann T Bothe H Abel J 20399894 PubMed Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta 2010 Gadaleta RM van Mil SW Oldenburg B Siersema PD Klomp LW van Erpecum KJ 21420387 PubMed 21420387 PubMed From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol 2011 Bock KW peroxisome proliferator-activated receptor signaling pathway PW:0001355 Pathway Ontology 19471584 PubMed Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nucl Recept Signal 2009 Rochette-Egly C Germain P 14978251 PubMed Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol 2004 Echchgadda I Song CS Roy AK Chatterjee B 11903058 PubMed Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J 2002 Krogsdam AM Nielsen CA Neve S Holst D Helledie T Thomsen B Bendixen C Mandrup S Kristiansen K 12573484 PubMed 16289099 PubMed 16289099 PubMed Over-production of IFN-gamma and IL-12 in AhR-null mice. FEBS Lett 2005 Rodríguez-Sosa M Elizondo G López-Durán RM Rivera I Gonzalez FJ Vega L 19106115 PubMed Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. Drug Metab Dispos 2009 Han S Chiang JY 11991950 PubMed Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002 Drocourt L Ourlin JC Pascussi JM Maurel P Vilarem MJ 12573484 PubMed The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003 Pascussi JM Gerbal-Chaloin S Drocourt L Maurel P Vilarem MJ 15610735 PubMed A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell 2004 Xu RX Lambert MH Wisely BB Warren EN Weinert EE Waitt GM Williams JD Collins JL Moore LB Willson TM Moore JT 20399894 PubMed Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta 2010 Gadaleta RM van Mil SW Oldenburg B Siersema PD Klomp LW van Erpecum KJ 16197558 PubMed 16197558 PubMed Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl Recept 2005 Tachibana K Kobayashi Y Tanaka T Tagami M Sugiyama A Katayama T Ueda C Yamasaki D Ishimoto K Sumitomo M Uchiyama Y Kohro T Sakai J Hamakubo T Kodama T Doi T 21226706 PubMed 21226706 PubMed The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization. Br J Haematol 2011 Lindsey S Papoutsakis ET 11343253 PubMed 11343253 PubMed The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 2001 Sugatani J Kojima H Ueda A Kakizaki S Yoshinari K Gong QH Owens IS Negishi M Sueyoshi T 12611900 PubMed Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 2003 Maglich JM Parks DJ Moore LB Collins JL Goodwin B Billin AN Stoltz CA Kliewer SA Lambert MH Willson TM Moore JT 21124311 PubMed 21124311 PubMed Estrogen receptors: therapies targeted to receptor subtypes. Clin Pharmacol Ther 2011 Nilsson S Gustafsson JÅ 11803135 PubMed The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci 2002 PubMed The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci 2002 Cai Y Konishi T Han G Campwala KH French SW Wan YJ 15581595 PubMed 15581595 PubMed 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA 15541765 PubMed Mechanisms of glucocorticoid receptor signaling during inflammation. Mech Ageing Dev 2004 Smoak KA Cidlowski JA 11991950 PubMed Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002 Drocourt L Ourlin JC Pascussi JM Maurel P Vilarem MJ 17284330 PubMed CAR and PXR: the xenobiotic-sensing receptors. Steroids 2007 17284330 PubMed CAR and PXR: the xenobiotic-sensing receptors. Steroids 2007 Timsit YE Negishi M 18288955 PubMed Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab 2008 Pavek P Dvorak Z 12611900 PubMed Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 2003 12611900 PubMed Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 2003 Maglich JM Parks DJ Moore LB Collins JL Goodwin B Billin AN Stoltz CA Kliewer SA Lambert MH Willson TM Moore JT 15581595 PubMed 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 17944540 PubMed AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem Res Toxicol 2007 Hockley SL Arlt VM Brewer D Te Poele R Workman P Giddings I Phillips DH 12573486 PubMed Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 2003 Mimura J Fujii-Kuriyama Y 20619336 PubMed Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Toxicol In Vitro 2010 Le Vee M Jouan E Fardel O 15340055 PubMed 11120824 PubMed The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol 2000 Jeon MS Esser C 17595319 PubMed The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. Mol Endocrinol 2007 Echchgadda I Song CS Oh T Ahmed M De La Cruz IJ Chatterjee B 15501915 PubMed 15501915 PubMed Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc Natl Acad Sci U S A 2004 Wang JC Derynck MK Nonaka DF Khodabakhsh DB Haqq C Yamamoto KR 11803135 PubMed The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci 2002 Cai Y Konishi T Han G Campwala KH French SW Wan YJ 15598615 PubMed Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environ Health Perspect 2004 Vezina CM Walker NJ Olson JR 15897893 PubMed TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene 2005 Weiss C Faust D Dürk H Kolluri SK Pelzer A Schneider S Dietrich C Oesch F Göttlicher M 19129222 PubMed Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. Nucleic Acids Res 2009 19129222 PubMed Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. Nucleic Acids Res 2009 Hariparsad N Chu X Yabut J Labhart P Hartley DP Dai X Evers R