PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2878 CPTAC Assay Portal]c2fab0ddfa4dab0a7bab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0ab0b6aperoxisome proliferator-activated receptor signaling pathwayPW:0001355Pathway Ontology15489539PubMedPPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.J Lipid Res2004Li ACGlass CK14999402PubMedPeroxisome proliferator-activated receptor alpha target genes.Cell Mol Life Sci2004Mandard SMüller MKersten S16197558PubMedGene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.Nucl Recept2005Tachibana KKobayashi YTanaka TTagami MSugiyama AKatayama TUeda CYamasaki DIshimoto KSumitomo MUchiyama YKohro TSakai JHamakubo TKodama TDoi T24261707PubMedPathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.Curr Drug Metab2013Fijten RRJennen DGvan Delft JH21420387PubMedFrom differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.Biochem Pharmacol2011Bock KW15581595PubMedRegulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.Arch Biochem Biophys2005Handschin CMeyer UA