The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2879).cc1nuclear receptor subfamily 1, group H, member 4 fa4T3nuclear receptor subfamily 1, group H, member 4fa4retinoid X receptor, alpha nuclear receptor subfamily 1, group H, member 4fa4retinoid X receptor, alpha nuclear receptor subfamily 1, group H, member 4 fa4retinoid X receptor, alpha UDP glucuronosyltransferase 2 family, polypeptide B4 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 solute carrier family 27 (fatty acid transporter), member 5 solute carrier family 10 (sodium/bile acid cotransporter), member 1 cytochrome P450, family 7, subfamily A, polypeptide 1 cd6nuclear receptor subfamily 0, group B, member 2 b6afibroblast growth factor 19 bedinsulin receptor substrate 2 ATP-binding cassette, sub-family B (MDR/TAP), member 11bile acid CoA:amino acid N-acyltransferasecytochrome P450, family 3, subfamily A, polypeptide 4 cd6FK506 binding protein 5 inositol hexakisphosphate kinase 3ATP-binding cassette, sub-family B (MDR/TAP), member 4nuclear receptor subfamily 0, group B, member 2peroxisome proliferator-activated receptor gamma, coactivator 1 alphab6asolute carrier organic anion transporter family, member 2B1 cytochrome P450, family 8, subfamily B, polypeptide 1 19471584PubMedDynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).Nucl Recept Signal2009Rochette-Egly CGermain P19106115PubMedMechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.Drug Metab Dispos2009Han SChiang JY11803135PubMedThe role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.Eur J Pharm Sci2002Cai YKonishi THan GCampwala KHFrench SWWan YJ17944540PubMedAHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.Chem Res 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