The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2879 CPTAC Assay Portal] cc1 nuclear receptor subfamily 1, group H, member 4 db8 T3 nuclear receptor subfamily 1, group H, member 4 db8 retinoid X receptor, alpha nuclear receptor subfamily 1, group H, member 4 db8 retinoid X receptor, alpha nuclear receptor subfamily 1, group H, member 4 db8 retinoid X receptor, alpha UDP glucuronosyltransferase 2 family, polypeptide B4 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 solute carrier family 27 (fatty acid transporter), member 5 solute carrier family 10 (sodium/bile acid cotransporter), member 1 cytochrome P450, family 7, subfamily A, polypeptide 1 cd6 nuclear receptor subfamily 0, group B, member 2 cd6 fibroblast growth factor 19 cd6 insulin receptor substrate 2 ATP-binding cassette, sub-family B (MDR/TAP), member 11 bile acid CoA:amino acid N-acyltransferase cytochrome P450, family 3, subfamily A, polypeptide 4 cd6 FK506 binding protein 5 inositol hexakisphosphate kinase 3 ATP-binding cassette, sub-family B (MDR/TAP), member 4 nuclear receptor subfamily 0, group B, member 2 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha cd6 solute carrier organic anion transporter family, member 2B1 cytochrome P450, family 8, subfamily B, polypeptide 1 db8 db8 db8 db8 bile acid signaling pathway PW:0001093 Pathway Ontology 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 20399894 PubMed Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta 2010 Gadaleta RM van Mil SW Oldenburg B Siersema PD Klomp LW van Erpecum KJ 15581595 PubMed Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005 Handschin C Meyer UA