The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2881 CPTAC Assay Portal] f48 aca aca estrogen signaling pathway PW:0000507 Pathway Ontology 24261707 PubMed Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab 2013 Fijten RR Jennen DG van Delft JH 21124311 PubMed Estrogen receptors: therapies targeted to receptor subtypes. Clin Pharmacol Ther 2011 Nilsson S Gustafsson JÃ…