NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2884 CPTAC Assay Portal]a1bc52a7ba7ba7ba7ba7ba10a7ba7bregulatory pathwayPW:0000004Pathway Ontologynuclear factor, erythroid 2 like 2 signaling pathwayPW:0000369Pathway Ontology24261707PubMedPathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.Curr Drug Metab2013Fijten RRJennen DGvan Delft JH19321346PubMedNRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.Trends Biochem Sci2009Hayes JDMcMahon M15923610PubMedThe GI-GPx gene is a target for Nrf2.Mol Cell Biol2005Banning ADeubel SKluth DZhou ZBrigelius-Flohe R21420387PubMedFrom differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.Biochem Pharmacol2011Bock KW21189866PubMedNrf2 target genes are induced under marginal selenium-deficiency.Genes Nutr2010Mueller MBanning ABrigelius-Flohe RKipp A