The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013). dc6 fc5 signaling pathway PW:0000003 Pathway Ontology 22554198 PubMed The IGF1 pathway genes and their association with age of puberty in cattle. Anim Genet 2013 Fortes MR Li Y Collis E Zhang Y Hawken RJ 7758431 PubMed Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995 Jones JI Clemmons DR