Based on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptors (bottom panel) to mediate cell-to-cell communications.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2911 CPTAC Assay Portal].e16cell-extracellular matrix signaling pathwayPW:0000646Pathway Ontologyregulatory pathwayPW:0000004Pathway Ontology25403569PubMedPotential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis.Sci Rep2014Li YZhang Z