Based on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptors (bottom panel) to mediate cell-to-cell communications. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2911). e16 25403569 PubMed Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis. Sci Rep 2014 Li Y Zhang Z regulatory pathway PW:0000004 Pathway Ontology cell-extracellular matrix signaling pathway PW:0000646 Pathway Ontology