Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases. Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Proteasome). This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP183_r95110 WP183 (r95110)] with a 86.0% conversion rate. e91 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5699 No homologues found for original id L:7316 No homologues found for original id L:8335 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118939 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5683 No homologues found for original id S:P0CG48 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3135 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5720 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5689 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5686 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3133 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5718 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5715 PRS6 HUMAN Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7320 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5696 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5713 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5692 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7323 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5717 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7317 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6184 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5702 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3015 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5690 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5698 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3458 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5684 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154277 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3105 No homologues found for original id L:5716 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3134 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5709 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5719 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7322 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6185 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3014 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9861 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5688 No homologues found for original id L:5682 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7318 U13393 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5694 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5687 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5693 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10197 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5700 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5711 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7321 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4734 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5706 PRS6 HUMAN Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5704 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5710 No homologues found for original id En:ENSG00000170315 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3107 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5685 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5721 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5695 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5707 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5701 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3106 No homologues found for original id L:5691 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5708 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5714 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705 e3b

22307589 PubMed Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A 2012 Lasker K Förster F Bohn S Walzthoeni T Villa E Unverdorben P Beck F Aebersold R Sali A Baumeister W ubiquitin/proteasome degradation pathway PW:0000144 Pathway Ontology 11017125 PubMed Basic Medical Research Award. The ubiquitin system. Nat Med 2000 Hershko A Ciechanover A Varshavsky A