This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär. This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2011_r75253 WP2011(75253)] with a 100.0% conversion rate. a85 f4e e2a e38 e5b f33 bd0 d21 ac5 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109819 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077463 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025434 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5562 Transcription Factor Transcription Factor Transcription Factor 20855588 PubMed MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci U S A 2010 Horie T Ono K Horiguchi M Nishi H Nakamura T Nagao K Kinoshita M Kuwabara Y Marusawa H Iwanaga Y Hasegawa K Yokode M Kimura T Kita T 20595232 PubMed Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 2010 Walker AK Yang F Jiang K Ji JY Watts JL Purushotham A Boss O Hirsch ML Ribich S Smith JJ Israelian K Westphal CH Rodgers JT Shioda T Elson SL Mulligan P Najafi-Shoushtari H Black JC Thakur JK Kadyk LC Whetstine JR Mostoslavsky R Puigserver P Li X Dyson NJ Hart AC N√§√§r AM 17646659 PubMed Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A 2007 Rodgers JT Puigserver P 18046414 PubMed mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007 Cunningham JT Rodgers JT Arlow DH Vazquez F Mootha VK Puigserver P 10.1038/nm0207-128 DOI Receptor feasts on sugar and cholesterol. Nature Medicine 2007 Joseph T Rodgers Pere Puigserver 20732877 PubMed Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 2010 Gerin I Clerbaux LA Haumont O Lanthier N Das AK Burant CF Leclercq IA MacDougald OA Bommer GT 16799563 PubMed An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 2006 Yang F Vought BW Satterlee JS Walker AK Jim Sun ZY Watts JL DeBeaumont R Saito RM Hyberts SG Yang S Macol C Iyer L Tjian R van den Heuvel S Hart AC Wagner G N√§√§r AM homeostasis pathway PW:0000355 Pathway Ontology 17581637 PubMed SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J 2007 Kim D Nguyen MD Dobbin MM Fischer A Sananbenesi F Rodgers JT Delalle I Baur JA Sui G Armour SM Puigserver P Sinclair DA Tsai LH 17347648 PubMed Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 2007 Gerhart-Hines Z Rodgers JT Bare O Lerin C Kim SH Mostoslavsky R Alt FW Wu Z Puigserver P