This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2011_r75253 WP2011(75253)] with a 100.0% conversion rate.
a85
f4e
e2a
e38
e5b
f33
bd0
d21
ac5
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109819
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077463
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025434
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5562
Transcription Factor
Transcription Factor
Transcription Factor
20855588
PubMed
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.
Proc Natl Acad Sci U S A
2010
Horie T
Ono K
Horiguchi M
Nishi H
Nakamura T
Nagao K
Kinoshita M
Kuwabara Y
Marusawa H
Iwanaga Y
Hasegawa K
Yokode M
Kimura T
Kita T
20595232
PubMed
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Genes Dev
2010
Walker AK
Yang F
Jiang K
Ji JY
Watts JL
Purushotham A
Boss O
Hirsch ML
Ribich S
Smith JJ
Israelian K
Westphal CH
Rodgers JT
Shioda T
Elson SL
Mulligan P
Najafi-Shoushtari H
Black JC
Thakur JK
Kadyk LC
Whetstine JR
Mostoslavsky R
Puigserver P
Li X
Dyson NJ
Hart AC
Näär AM
17646659
PubMed
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Proc Natl Acad Sci U S A
2007
Rodgers JT
Puigserver P
18046414
PubMed
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.
Nature
2007
Cunningham JT
Rodgers JT
Arlow DH
Vazquez F
Mootha VK
Puigserver P
10.1038/nm0207-128
DOI
Receptor feasts on sugar and cholesterol.
Nature Medicine
2007
Joseph T Rodgers
Pere Puigserver
20732877
PubMed
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
J Biol Chem
2010
Gerin I
Clerbaux LA
Haumont O
Lanthier N
Das AK
Burant CF
Leclercq IA
MacDougald OA
Bommer GT
16799563
PubMed
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Nature
2006
Yang F
Vought BW
Satterlee JS
Walker AK
Jim Sun ZY
Watts JL
DeBeaumont R
Saito RM
Hyberts SG
Yang S
Macol C
Iyer L
Tjian R
van den Heuvel S
Hart AC
Wagner G
Näär AM
homeostasis pathway
PW:0000355
Pathway Ontology
17581637
PubMed
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
EMBO J
2007
Kim D
Nguyen MD
Dobbin MM
Fischer A
Sananbenesi F
Rodgers JT
Delalle I
Baur JA
Sui G
Armour SM
Puigserver P
Sinclair DA
Tsai LH
17347648
PubMed
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
EMBO J
2007
Gerhart-Hines Z
Rodgers JT
Bare O
Lerin C
Kim SH
Mostoslavsky R
Alt FW
Wu Z
Puigserver P