By hijacking CBF-b, Vif (Viral infectivity factor, HIV protein) is manipulating the ubquitination machinery and adversely effecting host transcriptional regulation.
This pathways was adapted from figure 3 in [https://www.ncbi.nlm.nih.gov/pubmed/23352243 Fraser et al]. Viral proteins are highlighted in yellow.f0cregulatory pathwayPW:0000004Pathway Ontologyhuman immunodeficiency virus infectious diseaseDOID:526Human Disease Ontology23352243PubMedFrom systems to structure: bridging networks and mechanism.Mol Cell2013Fraser JSGross JDKrogan NJ