Interplay of RAC1, p38 MAPK, PAK1 and MMP2 in cell signaling pathways downstream of TEK receptor activity related to tumor growth, angiogenesis, and cell proliferation. These processes are reduced in RAC1 inactivated models of ovarian cancer. Gonzalez-Villasana, et al. Clin Cancer Res, 2015.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3303 CPTAC Assay Portal]da7disease pathwayPW:0000013Pathway Ontologycancer pathwayPW:0000605Pathway Ontologyovarian cancerDOID:2394Human Disease Ontologysignaling pathwayPW:0000003Pathway Ontology25595279PubMedRac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.Clin Cancer Res2015Gonzalez-Villasana VFuentes-Mattei EIvan CDalton HJRodriguez-Aguayo CFernandez-de Thomas RJAslan BDel C Monroig PVelazquez-Torres GPrevis RAPradeep SKahraman NWang HKanlikilicer POzpolat BCalin GSood AKLopez-Berestein G