Interplay of RAC1, p38 MAPK, PAK1 and MMP2 in cell signaling pathways downstream of TEK receptor activity related to tumor growth, angiogenesis, and cell proliferation. These processes are reduced in RAC1 inactivated models of ovarian cancer. Gonzalez-Villasana, et al. Clin Cancer Res, 2015. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3303 ). da7 25595279 PubMed Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. Clin Cancer Res 2015 Gonzalez-Villasana V Fuentes-Mattei E Ivan C Dalton HJ Rodriguez-Aguayo C Fernandez-de Thomas RJ Aslan B Del C Monroig P Velazquez-Torres G Previs RA Pradeep S Kahraman N Wang H Kanlikilicer P Ozpolat B Calin G Sood AK Lopez-Berestein G ovarian cancer DOID:2394 Disease cancer pathway PW:0000605 Pathway Ontology signaling pathway PW:0000003 Pathway Ontology disease pathway PW:0000013 Pathway Ontology