This pathway was created using the [GPCRDB](http://www.gpcr.org/7tm/) (Horn et al., 1998), (originally at the [CMBI](http://www.cmbi.kun.nl/7tm/)). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. b92 c3c

9399852 PubMed GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res 1998 Horn F Weare J Beukers MW Hörsch S Bairoch A Chen W Edvardsen O Campagne F Vriend G G protein mediated signaling pathway PW:0000125 Pathway Ontology 11836223 PubMed Classifying G-protein coupled receptors with support vector machines. Bioinformatics 2002 Karchin R Karplus K Haussler D