Ovarian bottleneck genes associated with infertility.
A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under mutation type) causing infertility (infertile - ovarian defect, under female fertility status) in mice (under species), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP34 CPTAC Assay Portal]
d61
f74
e77
df3
df3
df3
b04
e77
df3
d61
oocyte
CL:0000023
Cell Type
34501340
PubMed
FMR1 and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response
DOI: 10.3390/jcm10173892
2021
Rehnitz J
Capp E
Messmer B
Nguyen XP
Germeyer A
Freis A
Dietrich JE
Hinderhofer K
Strowitzki T
Vogt PH
34786213
PubMed
lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1
DOI: 10.1016/j.omtn.2021.10.015
2021
Li D
Xu W
Wang X
Dang Y
Xu L
Lu G
Chan WY
Leung PCK
Zhao S
Qin Y
34501340
PubMed
FMR1 and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response
DOI: 10.3390/jcm10173892
2021
Rehnitz J
Capp E
Messmer B
Nguyen XP
Germeyer A
Freis A
Dietrich JE
Hinderhofer K
Strowitzki T
Vogt PH
granulosa cell
CL:0000501
Cell Type
32403258
PubMed
Combining Bioinformatics and Experiments to Identify CREB1 as a Key Regulator in Senescent Granulosa Cells
DOI: 10.3390/diagnostics10050295
2020
Lin PH
Lin L
Li C
Kao PG
Tsai HW
Chen SN
Wen ZH
Wang P
Tsui KH
urogenital disease pathway
PW:0001699
Pathway Ontology
infertility
DOID:5223
Disease
30992313
PubMed
High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells
doi: 10.1074/mcp.RA119
2019
Elzaiat M
Herman L
Legois B
Léger T
Todeschini AL
Veitia RA