Ovarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under mutation type) causing infertility (infertile - ovarian defect, under female fertility status) in mice (under species), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP34 CPTAC Assay Portal] d61 f74 e77 df3 df3 df3 b04 e77 df3 d61 oocyte CL:0000023 Cell Type 34501340 PubMed FMR1 and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response DOI: 10.3390/jcm10173892 2021 Rehnitz J Capp E Messmer B Nguyen XP Germeyer A Freis A Dietrich JE Hinderhofer K Strowitzki T Vogt PH 34786213 PubMed lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1 DOI: 10.1016/j.omtn.2021.10.015 2021 Li D Xu W Wang X Dang Y Xu L Lu G Chan WY Leung PCK Zhao S Qin Y 34501340 PubMed FMR1 and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response DOI: 10.3390/jcm10173892 2021 Rehnitz J Capp E Messmer B Nguyen XP Germeyer A Freis A Dietrich JE Hinderhofer K Strowitzki T Vogt PH granulosa cell CL:0000501 Cell Type 32403258 PubMed Combining Bioinformatics and Experiments to Identify CREB1 as a Key Regulator in Senescent Granulosa Cells DOI: 10.3390/diagnostics10050295 2020 Lin PH Lin L Li C Kao PG Tsai HW Chen SN Wen ZH Wang P Tsui KH urogenital disease pathway PW:0001699 Pathway Ontology infertility DOID:5223 Disease 30992313 PubMed High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells doi: 10.1074/mcp.RA119 2019 Elzaiat M Herman L Legois B Léger T Todeschini AL Veitia RA