The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP357 CPTAC Assay Portal]aka (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]aka 3-oxo-fatty acyl-CoA(4−)cacUsed in small tissue samples as [14C] isotope tracer to improve sensiticity of FASN activity. [https://doi.org/10.1515/bchm3.1986.367.2.905]caccaccaccaccaccaccaccac3790257PubMedFatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.Biol Chem Hoppe Seyler1986Weiss LHoffmann GESchreiber RAndres HFuchs EKörber EKolb HJfatty acid biosynthetic pathwayPW:0000029Pathway Ontology