Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway
Pathway adapted from [http://www.kegg.jp/kegg-bin/show_pathway?map00270 KEGG].
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3580 CPTAC Assay Portal]aecec08393662PubMedCharacterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.Biochem J1993Alvarez LCorrales FMartin-Duce AMato JMclassic metabolic pathwayPW:0000002Pathway Ontologymethionine biosynthetic pathwayPW:0001301Pathway Ontologymap00270KEGG PathwayCysteine and methionine metabolismhttps://www.kegg.jp/dbget-bin/www_bget?pathway+map00270