Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery.
A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.b9aregulatory pathwayPW:0000004Pathway Ontology26655797PubMedA genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.Mol Syst Biol2015Shields BBPecot CVGao HMcMillan EPotts MNagel CPurinton SWang YIvan CKim HSBorkowski RJKhan SRodriguez-Aguayo CLopez-Berestein GLea JGazdar ABaggerly KASood AKWhite MA