Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1.
A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC Assay Portal].fb3regulatory pathwayPW:0000004Pathway Ontology26655797PubMedA genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.Mol Syst Biol2015Shields BBPecot CVGao HMcMillan EPotts MNagel CPurinton SWang YIvan CKim HSBorkowski RJKhan SRodriguez-Aguayo CLopez-Berestein GLea JGazdar ABaggerly KASood AKWhite MA