Lung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3624 CPTAC Assay Portal] a1e Link to the pathway Endochondrial ossification describing chondrocyte differentiation. Chondrocytes produce and maintain cartilage consisting mainly of collagen and proteoglycans. f5d Link to Elastic fibre formation, which describes the dynamic connective tissues such as large arteries and lung parenchyma. The stress fibre assembly related gene ELN is involved in this pathway. a8b f19 f4a f4a f4a f4a f19 Associated with MIE in AOP for pulmonary fibrosis be6 f19 Fourty-two particles and soluble chemicals are associated with pulmonary fibrosis in CTD a89 The genes are the result of comparison between 42 particles (e.g. asbestos, silica dust and carbon nanotubes) and soluble chemicals (e.g. belomycin and paraquat) associated with pulmonary fibrosis in the Comparative Toxicogenomics Database (http://ctdbase.org/). The connections between the genes and gene groups have been drawn based on information in the GeneMANIA database (http://www.genemania.org/). a89 c77 Associated with KE1 and KE2 in AOP for pulmonary fibrosis be6 Associated with KE1 in AOP for pulmonary fibrosis be6 Associated with KE1 and KE3 in AOP for pulmonary fibrosis be6 Associated with KE1 and KE3 in AOP for pulmonary fibrosis be6 Associated with KE1 and KE2 in AOP for pulmonary fibrosis be6 Associated with KE3 and KE4 in AOP for pulmonary fibrosis be6 Associated with KE3 in AOP for pulmonary fibrosis be6 Associated with KE3 and KE4 in AOP for pulmonary fibrosis be6 Associated with KE3 in AOP for pulmonary fibrosis be6 Associated with KE4 in AOP for pulmonary fibrosis be6 Associated with KE4 in AOP for pulmonary fibrosis be6 Associated with KE5 in AOP for pulmonary fibrosis be6 AO in AOP for pulmonary fibrosis be6 Associated with AE1 (Associative Event) in AOP for pulmonary fibrosis be6 Associated with AE1 (Associative Event) in AOP for pulmonary fibrosis be6 Associated with AE1 (Associative Event) in AOP for pulmonary fibrosis be6 Associated with AE2 (Associative Event) in AOP for pulmonary fibrosis be6 Associated with AE1 (Associative Event) in AOP for pulmonary fibrosis be6 Associated with KE3 and KE4 in AOP for pulmonary fibrosis be6 Associated with KE3 and KE4 in AOP for pulmonary fibrosis be6 Associated with KE3 in AOP for pulmonary fibrosis be6 Adverse Outcome Pathway relevance be6 Associated with AE1 (Associative Event) in AOP for pulmonary fibrosis This KE was not included in the first draft of the AOP and thus not included in the analyses resulting in this WikiPathway a1e pulmonary fibrosis DOID:3770 Human Disease Ontology respiratory system disease pathway PW:0001308 Pathway Ontology carbon nanotube response pathway PW:0001436 Pathway Ontology 29149350 PubMed A data fusion pipeline for generating and enriching Adverse Outcome Pathway descriptions. Toxicol Sci 2017 Nymark P Rieswijk L Ehrhart F Jeliazkova N Tsiliki G Sarimveis H Evelo CT Hongisto V Kohonen P Willighagen E Grafström RC 26979667 PubMed Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes http://www.ncbi.nlm.nih.gov/pubmed/26979667 2016 Labib S Williams A Yauk CL Nikota JK Wallin H Vogel U Halappanavar S 22824096 PubMed Molecular and cellular mechanisms of pulmonary fibrosis. http://www.ncbi.nlm.nih.gov/pubmed/22824096 2012 Todd NW Luzina IG Atamas SP 25326323 PubMed The Comparative Toxicogenomics Database's 10th year anniversary: update 2015 http://www.ncbi.nlm.nih.gov/pubmed/25326323 2015 Davis AP Grondin CJ Lennon-Hopkins K Saraceni-Richards C Sciaky D2, King BL Wiegers TC2, Mattingly CJ 25254104 PubMed GeneMANIA: Fast gene network construction and function prediction for Cytoscape. http://www.ncbi.nlm.nih.gov/pubmed/25254104 2014 Montojo J Zuberi K Rodriguez H Bader GD Morris Q 8634065 PubMed The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. Bioessays. 1995 Dec;17(12):1039-48. 1995 Muir H. 18755000 PubMed Mechanisms of actin stress fibre assembly J Microsc. 2008 Sep;231(3):446-54. doi: 10.1111/j.1365-2818.2008.02057.x. 2008 Naumanen P, Lappalainen P, Hotulainen P 26926090 PubMed Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP). http://www.ncbi.nlm.nih.gov/pubmed/26926090 2016 Vietti G Lison D van den Brule S