The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Manually translated from human model from Zhang (Cell 2013) to mouse: Gimap2 and Lgals9 (light gray) have no mouse ortholog.
bd8
ee3
innate immune response pathway
PW:0000234
Pathway Ontology
Alzheimer disease pathway
PW:0000015
Pathway Ontology
microglial cell
CL:0000129
Cell Ontology
23622250
PubMed
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Cell
2013
Zhang B
Gaiteri C
Bodea LG
Wang Z
McElwee J
Podtelezhnikov AA
Zhang C
Xie T
Tran L
Dobrin R
Fluder E
Clurman B
Melquist S
Narayanan M
Suver C
Shah H
Mahajan M
Gillis T
Mysore J
MacDonald ME
Lamb JR
Bennett DA
Molony C
Stone DJ
Gudnason V
Myers AJ
Schadt EE
Neumann H
Zhu J
Emilsson V
30323343
PubMed
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Nat Immunol
2018
Ryu JK
Rafalski VA
Meyer-Franke A
Adams RA
Poda SB
Rios Coronado PE
Pedersen LØ
Menon V
Baeten KM
Sikorski SL
Bedard C
Hanspers K
Bardehle S
Mendiola AS
Davalos D
Machado MR
Chan JP
Plastira I
Petersen MA
Pfaff SJ
Ang KK
Hallenbeck KK
Syme C
Hakozaki H
Ellisman MH
Swanson RA
Zamvil SS
Arkin MR
Zorn SH
Pico AR
Mucke L
Freedman SB
Stavenhagen JB
Nelson RB
Akassoglou K