The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Manually translated from human model from Zhang (Cell 2013) to mouse: Gimap2 and Lgals9 (light gray) have no mouse ortholog. bd8 ee3 innate immune response pathway PW:0000234 Pathway Ontology Alzheimer disease pathway PW:0000015 Pathway Ontology microglial cell CL:0000129 Cell Ontology 23622250 PubMed Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell 2013 Zhang B Gaiteri C Bodea LG Wang Z McElwee J Podtelezhnikov AA Zhang C Xie T Tran L Dobrin R Fluder E Clurman B Melquist S Narayanan M Suver C Shah H Mahajan M Gillis T Mysore J MacDonald ME Lamb JR Bennett DA Molony C Stone DJ Gudnason V Myers AJ Schadt EE Neumann H Zhu J Emilsson V 30323343 PubMed Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol 2018 Ryu JK Rafalski VA Meyer-Franke A Adams RA Poda SB Rios Coronado PE Pedersen LØ Menon V Baeten KM Sikorski SL Bedard C Hanspers K Bardehle S Mendiola AS Davalos D Machado MR Chan JP Plastira I Petersen MA Pfaff SJ Ang KK Hallenbeck KK Syme C Hakozaki H Ellisman MH Swanson RA Zamvil SS Arkin MR Zorn SH Pico AR Mucke L Freedman SB Stavenhagen JB Nelson RB Akassoglou K