The paper describes insulin signaling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signaling under diabetic condition. Insulin signaling under normal condition is represented in WP3634.
The model has been converted to GPML using the PathSBML plugin from PathVisio, importing the model BIOMD0000000449 from the BioModels Database directly. The layout has been improved manually.c05diabetes mellitusDOID:9351Human Disease Ontologyinsulin signaling pathwayPW:0000143Pathway Ontologyfat cellCL:0000136Cell Ontology23400783PubMedInsulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.J Biol Chem2013BrÀnnmark CNyman EFagerholm SBergenholm LEkstrand EMCedersund GStrÄlfors P