Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/). * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC Assay Portal] a34 disease pathway PW:0000013 Pathway Ontology 27148389 PubMed How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Hepat Mon 2016 Poortahmasebi V Poorebrahim M Najafi S Jazayeri SM Alavian SM Arab SS Ghavami S Alavian SE Rezaei Moghadam A Amiri M hepatocellular carcinoma DOID:684 Disease