Pathway model based on hub miRNAs and their putative targets from network analysis.
* From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/).
* After topological analysis and network visualization in Cytoscape, the top hub genes were identified.
* miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.
Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC Assay Portal]a34disease pathwayPW:0000013Pathway Ontology27148389PubMedHow Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.Hepat Mon2016Poortahmasebi VPoorebrahim MNajafi SJazayeri SMAlavian SMArab SSGhavami SAlavian SERezaei Moghadam AAmiri Mhepatocellular carcinomaDOID:684Disease