This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.c8aGeneral TermSmall molecule inhibitor, see article for more information. Identifier not found27214381PubMedWnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells.PLoS One2016Kweon SMChi FHigashiyama RLai KTsukamoto Hsignaling pathwayPW:0000003Pathway Ontologyliver cirrhosisDOID:5082Diseasehepatic stellate cellCL:0000632Cell Type