This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis. c8a General Term Small molecule inhibitor, see article for more information. Identifier not found 27214381 PubMed Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One 2016 Kweon SM Chi F Higashiyama R Lai K Tsukamoto H signaling pathway PW:0000003 Pathway Ontology liver cirrhosis DOID:5082 Disease hepatic stellate cell CL:0000632 Cell Type