The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3658 CPTAC Assay Portal]b3eDKK Not SpecifiedTCF Not SpecifiedLEF Not SpecifiedFrizzled Not SpecifiedWnt Not SpecifiedAkt Not SpecifiedPYGO Not SpecifiedleukemiaDOID:1240Human Disease Ontologyaltered Wnt signaling pathwayPW:0000598Pathway Ontology18800146PubMedTargeting the leukemic stem cell: the Holy Grail of leukemia therapy.Leukemia2009Misaghian NLigresti GSteelman LSBertrand FEBäsecke JLibra MNicoletti FStivala FMilella MTafuri ACervello MMartelli AMMcCubrey JA