The pathways hypothesized to be involved in cardiovascular diseases begin with LTBPs and fibrillins activating a TGFBR complex. The complex can begin the canonical TGFB pathway involving SMAD proteins that target gene expression for proteins involved in endocardial and epicardial EMT, neural crest migration, ECM remodeling, cell differentiation, development and maintenance of cardiovascular structure and function. The non-canonical TGFB pathway involves the calcium-calneurin signaling pathway that also affects those functions. The TGFBR complex also activates SHCA and Tak1, which promote the function of a complex (ERK1/2, JNK1, and p38) to regulate the previously mentioned cell functions and influence the development of cardiovascular diseases. These diseases are additionally influenced by a signaling pathway involving the activation of TGFB ligands, receptors, activators, and effectors by ANG2/AT1/2R complex. This pathway is based on figure 1 from Doetschman et al.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3668 CPTAC Assay Portal]ba6Firbrillins Not SpecifiedLTBP Not SpecifiedIdentifier Not FoundFirbrillins Not SpecifiedFirbrillins Not SpecifiedLTBP Not Specifiedcardiovascular system disease pathwayPW:0000020Pathway Ontologycardiomyopathy pathwayPW:0000022Pathway OntologyKawasaki diseaseDOID:13378Diseaseheart valve diseaseDOID:4079Disease21953136PubMedTransforming growth factor beta signaling in adult cardiovascular diseases and repair.Cell Tissue Res2012Doetschman TBarnett JVRunyan RBCamenisch TDHeimark RLGranzier HLConway SJAzhar Mcardiovascular system diseaseDOID:1287DiseasehypertensionDOID:10763DiseaseatherosclerosisDOID:1936Diseaseaortic aneurysmDOID:3627Diseasedisease pathwayPW:0000013Pathway OntologycardiomyopathyDOID:0050700Diseaseendocardial cellCL:0002350Cell Type