This pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Cells."(See Bibliography).The neuropeptide cholecystokinin (CCK) acts through its receptor CCK2R to achieve largely different functions in different types of cells. CCK, CCK2R, and CB1R have all been known to have substantial effects on anxiety and other mood disorders, and the PV+ interneurons have also been shown to be involved i na variety of cognitive functions. However, In PV+ basket cells and CCK+ basket cells, the CCK2 receptor uses different pathways to exert different effects on the two types of basket cells. For CCK+ basket cells, CCK2 receptors in neighboring pyramidal cells act through the Gq pathway to form endocannabinoids, which, through the cannabinoid receptor type 1 on the CCK+ basket cell, inhibit the release of the neurotransmitter GABA. In contrast, for PV+ basket cells, CCK2 receptors act through the pertussin-toxin sensitive Gi pathway to regulate the intracellular Ca²⁺ through ryanodine receptors. This pathway ultimately leads to activation of a non-selective cationic conductance to depolarize the PV+ basket cells. c18 receptor artifically added antagonist of cyclic ADPR gamma-Aminobutyric acid inhibitory neurotransmitter in mammalian CNS likely forms complexes with TRPC4 and TRPC5 transient receptor potential ion channel artificially added inhibitor of ryanodine receptor Cannabinoid receptor 1 receptor gamma-Aminobutyric acid inhibitory neurotransmitter in mammalian CNS gamma-Aminobutyric acid inhibitory neurotransmitter in mammalian CNS gamma-Aminobutyric acid inhibitory neurotransmitter in mammalian CNS ba3 signaling pathway PW:0000003 Pathway Ontology pyramidal neuron CL:0000598 Cell Type 21795548 PubMed Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells. J Neurosci 2011 Lee SY Földy C Szabadics J Soltesz I 21173082 PubMed Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells. J Physiol 2011 Lee SH Soltesz I basket cell CL:0000118 Cell Type pertussis DOID:1116 Disease