This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP384) f65 de1 e68 c94 ae8 cfb ace f54 Apoptosis Inducing Factor 10224227 PubMed Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J 1999 Schett G Steiner CW Gröger M Winkler S Graninger W Smolen J Xu Q Steiner G 14512773 PubMed HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle 2003 Garrido C Schmitt E Candé C Vahsen N Parcellier A Kroemer G 10934467 PubMed Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2000 Saleh A Srinivasula SM Balkir L Robbins PD Alnemri ES 14555980 PubMed Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 2003 Gurbuxani S Schmitt E Cande C Parcellier A Hammann A Daugas E Kouranti I Spahr C Pance A Kroemer G Garrido C apoptotic cell death pathway PW:0000009 Pathway Ontology 9821948 PubMed Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 1998 Gabai VL Meriin AB Yaglom JA Volloch VZ Sherman MY 15078873 PubMed The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem 2004 Orsini F Migliaccio E Moroni M Contursi C Raker VA Piccini D Martin-Padura I Pelliccia G Trinei M Bono M Puri C Tacchetti C Ferrini M Mannucci R Nicoletti I Lanfrancone L Giorgio M Pelicci PG 9799222 PubMed Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998 Jäättelä M Wissing D Kokholm K Kallunki T Egeblad M 10982831 PubMed The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 2000 Mosser DD Caron AW Bourget L Meriin AB Sherman MY Morimoto RI Massie B