This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP384 CPTAC Assay Portal]
f65
de1
e68
c94
ae8
cfb
ace
f54
Apoptosis Inducing Factor
9821948
PubMed
Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.
FEBS Lett
1998
Gabai VL
Meriin AB
Yaglom JA
Volloch VZ
Sherman MY
9799222
PubMed
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J
1998
Jäättelä M
Wissing D
Kokholm K
Kallunki T
Egeblad M
10982831
PubMed
The chaperone function of hsp70 is required for protection against stress-induced apoptosis.
Mol Cell Biol
2000
Mosser DD
Caron AW
Bourget L
Meriin AB
Sherman MY
Morimoto RI
Massie B
14512773
PubMed
HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.
Cell Cycle
2003
Garrido C
Schmitt E
Candé C
Vahsen N
Parcellier A
Kroemer G
10934467
PubMed
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Nat Cell Biol
2000
Saleh A
Srinivasula SM
Balkir L
Robbins PD
Alnemri ES
10224227
PubMed
Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.
FASEB J
1999
Schett G
Steiner CW
Gröger M
Winkler S
Graninger W
Smolen J
Xu Q
Steiner G
14555980
PubMed
Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.
Oncogene
2003
Gurbuxani S
Schmitt E
Cande C
Parcellier A
Hammann A
Daugas E
Kouranti I
Spahr C
Pance A
Kroemer G
Garrido C
apoptotic cell death pathway
PW:0000009
Pathway Ontology
15078873
PubMed
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
J Biol Chem
2004
Orsini F
Migliaccio E
Moroni M
Contursi C
Raker VA
Piccini D
Martin-Padura I
Pelliccia G
Trinei M
Bono M
Puri C
Tacchetti C
Ferrini M
Mannucci R
Nicoletti I
Lanfrancone L
Giorgio M
Pelicci PG