This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3844). e9f signaling pathway PW:0000003 Pathway Ontology prostate cancer DOID:10283 Disease 24759575 PubMed PI3K-AKT-mTOR singaling in prostate cancer progression and androgen deprivation therapy resistance NIH 2014 Merritt P Edlind Andrew C Hsieh disease pathway PW:0000013 Pathway Ontology phosphatidylinositol 3-kinase signaling pathway PW:0000595 Pathway Ontology phosphatidylinositol 3-kinase-Akt signaling pathway PW:0000232 Pathway Ontology cancer pathway PW:0000605 Pathway Ontology