This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects. b22 b30 Proposed Inhibition eb5 Wnt signaling, the planar cell polarity pathway PW:0000200 Pathway Ontology 23169527 PubMed The β-catenin destruction complex. Cold Spring Harb Perspect Biol 2013 Stamos JL Weis WI Wnt signaling pathway PW:0000008 Pathway Ontology disease pathway PW:0000013 Pathway Ontology 20091054 PubMed Glomerulocystic kidney disease. Pediatr Nephrol 2010 Bissler JJ Siroky BJ Yin H kidney disease DOID:557 Disease 18371931 PubMed Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008 Bergmann C Fliegauf M Brüchle NO Frank V Olbrich H Kirschner J Schermer B Schmedding I Kispert A Kränzlin B Nürnberg G Becker C Grimm T Girschick G Lynch SA Kelehan P Senderek J Neuhaus TJ Stallmach T Zentgraf H Nürnberg P Gretz N Lo C Lienkamp S Schäfer T Walz G Benzing T Zerres K Omran H