Endogenous cannabinoid receptors belong to the endocannabinoid system and are located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The endocannabinoid system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. Two primary endocannabinoid receptors have been identified: CNR1 and CNR2. CNR1 is found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC (tetrahydrocannabinol). One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD (cannabidiol). 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management. Source: https://en.wikipedia.org/wiki/Endocannabinoid_system Not all MAPK subtypes are relevant for this pathway. The relevant types have been separately added on the right side of the pathway. Source: Howlett A.C. Cannabinoid Receptor Signaling. In: Pertwee R.G. (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. Springer, Berlin, Heidelberg, 2005 bff f43 b2b f43 bff f43 e7f d25 dd7 bff bff bff bff bff bff bff ef5 cannabinoid signaling pathway PW:0001163 Pathway Ontology 27106177 PubMed Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products. Clin Pharmacokinet 2016 Anderson GD Chan LN PubMed http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2 26218440 PubMed Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol 2015 Laprairie RB Bagher AM Kelly ME Denovan-Wright EM 21704641 PubMed Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci 2011 Jiang R Yamaori S Takeda S Yamamoto I Watanabe K 23108542 PubMed Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development. Philos Trans R Soc Lond B Biol Sci 2012 Díaz-Alonso J Guzmán M Galve-Roperh I 16672367 PubMed Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci U S A 2006 Carrier EJ Auchampach JA Hillard CJ leukocyte CL:0000738 Cell Type xenobiotic metabolic pathway PW:0001229 Pathway Ontology neuron CL:0000540 Cell Type 26187180 PubMed Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells. Life Sci 2015 Yamaori S Kinugasa Y Jiang R Takeda S Yamamoto I Watanabe K