The proximal tubule of the nephron reabsorbs approximately two-thirds of the Na filtered through the glomerulus. Na extrusion from the cell by the basolateral Na/K-ATPase provides the gradient for apical Na entry, and for reabsorption of glucose, phosphate, amino acids and other component of the ultrafiltrate. This pathway organizes several of the transporters present in the proximal tubule by their function and it is based in deep-sequencing and physiological data. e5d f7e ba4 ca4 ion transport pathway PW:0001348 Pathway Ontology nephron tubule epithelial cell CL:1000494 Cell Ontology transport pathway PW:0000103 Pathway Ontology regulatory pathway PW:0000004 Pathway Ontology epithelial cell of proximal tubule CL:0002306 Cell Ontology kidney proximal convoluted tubule epithelial cell CL:1000838 Cell Ontology 17164835 PubMed The role of carbonic anhydrases in renal physiology. Kidney Int 2007 Purkerson JM Schwartz GJ 17002596 PubMed Specificity and regulation of renal sulfate transporters. Annu Rev Physiol 2007 Markovich D Aronson PS 23908456 PubMed Proximal tubule function and response to acidosis. Clin J Am Soc Nephrol 2014 Curthoys NP Moe OW 25817355 PubMed Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol 2015 Lee JW Chou CL Knepper MA