The thick ascending limb of the loop pf Henle reabsorbs 25 to 30 % of the NaCl filtered through the glomerulus. Abnormally elevated Na reabsorption by this segment is link to salt-sensitive hypertension. Ang II is an important regulator of transport in the thick ascending limb, in part due to its modulatory effects on the balance between nitric oxide and superoxide. This pathway features the acute effects of Ang II in NO and O2- production in thick ascending limb. The information presented here is based on both genomic and physiological data. aab cf7 b15 e61 d0d f34 bbc e6a f00 c25 c25 ba3 f75 bf4 c95 a24 daa c84 b57 ca7 aa1 d53 d70 d4c adb d5e b6d dea f6c c15 b67 fe2 ed1 f35 db4 dc5 angiotensin signaling pathway PW:0000245 Pathway Ontology renin-angiotensin cascade pathway PW:0000492 Pathway Ontology signaling pathway PW:0000003 Pathway Ontology renal hypertension DOID:1073 Human Disease Ontology kidney loop of henle thick ascending limb epithelial cell CL:1001106 Cell Ontology 16894053 PubMed Superoxide stimulates NaCl absorption in the thick ascending limb via activation of protein kinase C. Hypertension 2006 Silva GB Ortiz PA Hong NJ Garvin JL 24370594 PubMed Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb. 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