Hfe, the mouse equivalent of the human hemochromatosis gene, is known to promote expression of hepcidin, a gene product that inhibits iron absorption, but it is not fully clear how it does this, or at which point Hfe interacts with the cycle(Hfe could be acting on the interaction at points A,B, or C). Hfe, as well as Tmprss6, another gene product, are used in the regulation of systemic iron homeostasis. Evidence obtained from gene testing on mice seems to indicate that Hfe inhibits Tmprss6, which is known to be an inhibitor of Hjv, a gene product that augments BMP/SMAD signaling for the production of hepcidin. Alternatively, Hfe may promote Bmp/Smad signaling by HJV, or by promoting signaling at a point past where Tmprss6 inhibits HJV. This pathway was inferred from Mus musculus pathway "Hfe effect on hepcidin production", WP3673 revision 87409, with a 88.0% conversion rate. a73 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016942 Hepcidin. Inhibits iron absorbtion Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050440 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039004 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025880 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042745 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611 regulatory pathway PW:0000004 Pathway Ontology regulatory pathway PW:0000004 Pathway Ontology iron homeostasis pathway PW:0000590 Pathway Ontology iron homeostasis pathway PW:0000590 Pathway Ontology 21355094 PubMed Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice NIH 2011 Karin E. Finberg Rebecca L. Wittlesey Nancy C. Andrews