Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal] This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate. f4f Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417 Siglece interacts with Ptpn6 according to BioGRID Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992 No homologues found for original id En:ENSMUSG00000041754 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046207 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698 Alzheimer disease pathway PW:0000015 Pathway Ontology innate immune response pathway PW:0000234 Pathway Ontology microglial cell CL:0000129 Cell Ontology 23622250 PubMed Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell 2013 Zhang B Gaiteri C Bodea LG Wang Z McElwee J Podtelezhnikov AA Zhang C Xie T Tran L Dobrin R Fluder E Clurman B Melquist S Narayanan M Suver C Shah H Mahajan M Gillis T Mysore J MacDonald ME Lamb JR Bennett DA Molony C Stone DJ Gudnason V Myers AJ Schadt EE Neumann H Zhu J Emilsson V