Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal]This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate.f4fHomology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417Siglece interacts with Ptpn6 according to BioGRIDHomology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992No homologues found for original id En:ENSMUSG00000041754Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046207Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698Alzheimer disease pathwayPW:0000015Pathway Ontologyinnate immune response pathwayPW:0000234Pathway Ontologymicroglial cellCL:0000129Cell Ontology23622250PubMedIntegrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.Cell2013Zhang BGaiteri CBodea LGWang ZMcElwee JPodtelezhnikov AAZhang CXie TTran LDobrin RFluder EClurman BMelquist SNarayanan MSuver CShah HMahajan MGillis TMysore JMacDonald MELamb JRBennett DAMolony CStone DJGudnason VMyers AJSchadt EENeumann HZhu JEmilsson V