Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3942 CPTAC Assay Portal] This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP2316 revision 69143, with a 92.0% conversion rate. e52 Original kegg element: gene;21;mmu:113868 mmu:235674 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674 Original kegg element: gene;16;mmu:19015 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015 Original kegg element: gene;18;mmu:19016 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016 Original kegg element: gene;62;mmu:22190 No homologues found for original id L:22190 Original kegg element: gene;9;mmu:18534 mmu:74551 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168 Original kegg element: gene;58;mmu:13124 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124 Original kegg element: gene;66;mmu:22227 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227 Original kegg element: gene;36;mmu:26457 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 Original kegg element: gene;37;mmu:15360 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 Original kegg element: gene;7;mmu:11832 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 Original kegg element: map;34;path:mmu04920 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30049 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065 Original kegg element: gene;59;mmu:22259 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739 Original kegg element: gene;41;mmu:57875 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875 Original kegg element: gene;60;mmu:104086 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140 Original kegg element: gene;22;mmu:11364 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 Original kegg element: gene;32;mmu:14077 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 Original kegg element: gene;63;mmu:13167 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458 Original kegg element: gene;36;mmu:26457 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 Original kegg element: gene;46;mmu:11807 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807 Original kegg element: gene;31;mmu:12491 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 Original kegg element: gene;44;mmu:14080 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 Original kegg element: gene;65;mmu:17436 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436 Original kegg element: gene;53;mmu:11450 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450 Original kegg element: gene;57;mmu:11814 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 Original kegg element: gene;14;mmu:19013 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013 Original kegg element: gene;56;mmu:56473 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 Original kegg element: gene;33;mmu:13122 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122 Original kegg element: gene;47;mmu:18830 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830 Original kegg element: gene;8;mmu:14626 mmu:14933 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933 Original kegg element: map;51;path:mmu00120 Original kegg element: gene;10;mmu:103968 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 Original kegg element: gene;64;mmu:66113 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 Original kegg element: gene;9;mmu:18534 mmu:74551 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534 Original kegg element: gene;26;mmu:12896 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 Original kegg element: gene;39;mmu:83995 mmu:83996 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996 Original kegg element: gene;29;mmu:108078 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639 Original kegg element: gene;11;mmu:12491 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 Original kegg element: gene;39;mmu:83995 mmu:83996 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 Original kegg element: gene;20;mmu:20280 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 Original kegg element: gene;30;mmu:16956 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956 Original kegg element: map;52;path:mmu00564 Original kegg element: gene;43;mmu:16202 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202 Original kegg element: gene;61;mmu:11806 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 Original kegg element: map;50;path:mmu00072 Original kegg element: gene;8;mmu:14626 mmu:14933 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 Original kegg element: map;35;path:mmu00071 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 Original kegg element: gene;38;mmu:20411 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411 Original kegg element: gene;40;mmu:11770 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592 Original kegg element: gene;25;mmu:74147 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 Original kegg element: gene;45;mmu:18607 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607 Original kegg element: gene;23;mmu:11363 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363 Original kegg element: gene;21;mmu:113868 mmu:235674 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 PCrel;1;14 activation; --> PCrel;4;15 activation; --> PCrel;49;17 activation; --> PCrel;49;17 activation; --> PCrel;4;15 activation; --> PCrel;4;15 activation; -->

signaling pathway PW:0000003 Pathway Ontology cell of skeletal muscle CL:0000188 Cell Ontology peroxisome proliferator-activated receptor signaling pathway PW:0001355 Pathway Ontology white fat cell CL:0000448 Cell Ontology 15828221 PubMed [PPARs-mediated intracellular signal transduction]. Nihon Rinsho 2005 Fujii H