Summary of findings for miR-509-3p and the YAP1/ECM axis. [Reference](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041955/). Collectively, the results suggest that miR-509-3p-mediated changes in levels of YAP1 and ECM genes impair migration, invasion, and spheroid formation and so may attenuate metastatic progression in advanced stage ovarian cancer. Further, results suggest that the direct downstream miR-509-3p target YAP1 is likely a critical driver of cellular migration and spheroid formation in ovarian cancers in which levels of YAP1 protein are high. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3967). afc Hippo signaling pathway PW:0001515 Pathway Ontology cancer pathway PW:0000605 Pathway Ontology cancer DOID:162 Disease 27036018 PubMed miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget 2016 Pan Y Robertson G Pedersen L Lim E Hernandez-Herrera A Rowat AC Patil SL Chan CK Wen Y Zhang X Basu-Roy U Mansukhani A Chu A Sipahimalani P Bowlby R Brooks D Thiessen N Coarfa C Ma Y Moore RA Schein JE Mungall AJ Liu J Pecot CV Sood AK Jones SJ Marra MA Gunaratne PH ovarian cancer DOID:2394 Disease