Summary of findings for miR-509-3p and the YAP1/ECM axis. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041955/
Collectively, the results suggest that miR-509-3p-mediated changes in levels of YAP1 and ECM genes impair migration, invasion, and spheroid formation and so may attenuate metastatic progression in advanced stage ovarian cancer. Further, results suggest that the direct downstream miR-509-3p target YAP1 is likely a critical driver of cellular migration and spheroid formation in ovarian cancers in which levels of YAP1 protein are high.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3967 CPTAC Assay Portal].afcovarian cancerDOID:2394Human Disease OntologyHippo signaling pathwayPW:0001515Pathway OntologycancerDOID:162Human Disease Ontologycancer pathwayPW:0000605Pathway Ontology27036018PubMedmiR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.Oncotarget2016Pan YRobertson GPedersen LLim EHernandez-Herrera ARowat ACPatil SLChan CKWen YZhang XBasu-Roy UMansukhani AChu ASipahimalani PBowlby RBrooks DThiessen NCoarfa CMa YMoore RASchein JEMungall AJLiu JPecot CVSood AKJones SJMarra MAGunaratne PH