This pathway was adapted from several resources and is designed to provide a theoretical framework to examine Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway is known drug targets that promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP399). ab3 e95 bdf Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629 a85 a5c ae0 16881513 PubMed Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Methods Mol Biol 2006 Sato N Brivanlou AH Wnt signaling pathway PW:0000008 Pathway Ontology 17372190 PubMed Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A 2007 Miyabayashi T Teo JL Yamamoto M McMillan M Nguyen C Kahn M 22539006 PubMed (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ 2012 Chen CY Weng YH Chien KY Lin KJ Yeh TH Cheng YP Lu CS Wang HL 18957414 PubMed 18957414 PubMed Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem 2008 Zhang X Zhang J Wang T Esteban MA Pei D canonical Wnt signaling pathway PW:0000201 Pathway Ontology pluripotent stem cell CL:0002248 Cell Type hsa04310 KEGG Pathway Kegg version of this pathway http://www.genome.jp/kegg/pathway/hsa/hsa04310.html 18483421 PubMed Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells 2008 Yi F Pereira L Merrill BJ