This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.
A central organizing theme of this pathway are known drug targets that promote self-renewal or pluripotency (BIO and IQ-1)
and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells.
Interactions and object/gene groups for the pathway exist for the majority of components.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP399 CPTAC Assay Portal].ab3e95bdfNon-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629a85a5cae0pluripotent stem cellCL:0002248Cell Ontologycanonical Wnt signaling pathwayPW:0000201Pathway OntologyWnt signaling pathwayPW:0000008Pathway Ontologyhsa04310KEGG PathwayKegg version of this pathwayhttp://www.genome.jp/kegg/pathway/hsa/hsa04310.html17372190PubMedWnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.Proc Natl Acad Sci U S A2007Miyabayashi TTeo JLYamamoto MMcMillan MNguyen CKahn M16881513PubMedManipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.Methods Mol Biol2006Sato NBrivanlou AH22539006PubMed(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.Cell Death Differ2012Chen CYWeng YHChien KYLin KJYeh THCheng YPLu CSWang HL18957414PubMedEsrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells.J Biol Chem2008Zhang XZhang JWang TEsteban MAPei D18483421PubMedTcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.Stem Cells2008Yi FPereira LMerrill BJ