The MAPK signaling proteins are involved in many eukaryotic cellular processes and signaling networks. The upstream activation pathways for ERK1 and ERK2 are highly similar, and also many of their known downstream targets are common; however these genes exhibit different knockdown phenotypes and there are diverse roles for these kinases during embryogenesis. For ERK1 specific genes are involved in dorsal-ventral patterning and subsequent embryonic cell migration. For ERK2, several genes are involved in cell-migration, mesendoderm differentiation and patterning. * = is not present in GenMAPP gene database # not represented in Agilent zebrafish 22K oligo set a7e a85

the extracellular signal-regulated Raf/Mek/Erk signaling pathway PW:0000102 Pathway Ontology 18442396 PubMed ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics 2008 Krens SF Corredor-Adamez M He S Snaar-Jagalska BE Spaink HP 16774848 PubMed Characterization and expression patterns of the MAPK family in zebrafish. Gene Expr Patterns 2006 Krens SF He S Spaink HP Snaar-Jagalska BE