This pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. ef5 dbf

9399852 PubMed GPCRDB: an information system for G protein-coupled receptors Nucleic Acids Research 1998 Horn F Weare J Beukers MW Hörsch S Bairoch A Chen W Edvardsen O Campagne F Vriend G. 11836223 PubMed Classifying G-protein coupled receptors with support vector machines Bioinformatics 2002 Karchin R Karplus K Haussler D G protein mediated signaling pathway PW:0000125 Pathway Ontology