Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
Based on [https://www.ncbi.nlm.nih.gov/pubmed/14519196 Zambon et al, Genome Biol. 2003;4(10):R61].
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP410 CPTAC Assay Portal]ac9102265 at93527 at95057 at96029 at100405 at101002 at97459 at104050 at101091 at93833 s at103501 at93933 at92925 at101101 at97843 at93866 s at93829 at162346 f at96564 at97261 at93392 at97681 f at94481 at104516 at104725 at94835 f at93872 at160309 at95424 at99583 at95508 at94889 at104116 at94454 at96269 at99532 at103888 at97531 at99076 at93104 at100535 at95096 at (mouse)regulatory pathwayPW:0000004Pathway Ontologycell of skeletal muscleCL:0000188Cell Ontology14519196PubMedTime- and exercise-dependent gene regulation in human skeletal muscle.Genome Biol2003Zambon ACMcDearmon ELSalomonis NVranizan KMJohansen KLAdey DTakahashi JSSchambelan MConklin BR11967526PubMedExtensive and divergent circadian gene expression in liver and heart.Nature2002Storch KFLipan OLeykin IViswanathan NDavis FCWong WHWeitz CJ12015981PubMedCoordinated transcription of key pathways in the mouse by the circadian clock.Cell2002Panda SAntoch MPMiller BHSu AISchook ABStraume MSchultz PGKay SATakahashi JSHogenesch JB