Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively. Based on [Zambon et al, Genome Biol. 2003;4(10):R61](https://www.ncbi.nlm.nih.gov/pubmed/14519196). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP410) ac9 104050 at 95508 at 104516 at 162346 f at 104116 at 101101 at 93872 at 92925 at 95057 at 96564 at 93829 at 95096 at (mouse) 94835 f at 94889 at 99532 at 94454 at 102265 at 96269 at 93527 at 99583 at 93104 at 97681 f at 93933 at 97843 at 101091 at 103888 at 103501 at 104725 at 99076 at 97459 at 94481 at 95424 at 160309 at 96029 at 100535 at 97261 at 93833 s at 93392 at 100405 at 97531 at 93866 s at 101002 at dee d87 cell of skeletal muscle CL:0000188 Cell Type 12015981 PubMed Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002 Panda S Antoch MP Miller BH Su AI Schook AB Straume M Schultz PG Kay SA Takahashi JS Hogenesch JB regulatory pathway PW:0000004 Pathway Ontology 11967526 PubMed Extensive and divergent circadian gene expression in liver and heart. Nature 2002 Storch KF Lipan O Leykin I Viswanathan N Davis FC Wong WH Weitz CJ 14519196 PubMed Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol 2003 Zambon AC McDearmon EL Salomonis N Vranizan KM Johansen KL Adey D Takahashi JS Schambelan M Conklin BR