This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4150 CPTAC Assay Portal]. This pathway was inferred from Mus musculus pathway [http://wikipathways.org/instance/WP3857_r90797 WP3857 (rev 90797)] with a 100.0% conversion rate. b22 b30 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032558 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000007815 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006932 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028344 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024913 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030201 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22408 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22409 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22410 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22421 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93735 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22420 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22418 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22414 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22411 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22417 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22416 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22419 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22412 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22413 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22415 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22422 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14362 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14370 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14366 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57265 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14369 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14371 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14367 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14368 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14362 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14370 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14366 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57265 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14369 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14371 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14367 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14368 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13543 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13544 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13542 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26419 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13543 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13544 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13542 Proposed Inhibition kidney disease DOID:557 Disease 18371931 PubMed Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008 Bergmann C Fliegauf M Brüchle NO Frank V Olbrich H Kirschner J Schermer B Schmedding I Kispert A Kränzlin B Nürnberg G Becker C Grimm T Girschick G Lynch SA Kelehan P Senderek J Neuhaus TJ Stallmach T Zentgraf H Nürnberg P Gretz N Lo C Lienkamp S Schäfer T Walz G Benzing T Zerres K Omran H 20091054 PubMed Glomerulocystic kidney disease. Pediatr Nephrol 2010 Bissler JJ Siroky BJ Yin H Wnt signaling, the planar cell polarity pathway PW:0000200 Pathway Ontology disease pathway PW:0000013 Pathway Ontology Wnt signaling pathway PW:0000008 Pathway Ontology signaling pathway PW:0000003 Pathway Ontology