Endometrial cancer (EC) is the most common gynecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4155 CPTAC Assay Portal] ce2 eaf a5c parentid=P04049; parentsymbol=RAF1; site=IGDFGLAtVksRWsG; position=thr491; sitegrpid=447748; ptm=p; direction=u parentid=P04049; parentsymbol=RAF1; site=RPRGQRDssyyWEIE; position=ser338; sitegrpid=447742; ptm=p; direction=u parentid=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u parentid=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u parentid=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGTRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u parentid=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u parentid=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u parentid=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u parentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u parentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u parentid=P19419; parentsymbol=ELK1; site=LsPIAPRsPAKLSFQ; position=ser389; sitegrpid=449757; ptm=p; direction=u parentid=P19419; parentsymbol=ELK1; site=IHFWSTLsPIAPRsP; position=ser383; sitegrpid=447872; ptm=p; direction=u parentid=P31749; parentsymbol=AKT1; site=RPHFPQFsysAsGtA; position=ser473; sitegrpid=447855; ptm=p; direction=u parentid=P31749; parentsymbol=AKT1; site=kDGAtMKtFCGtPEy; position=thr308; sitegrpid=447856; ptm=p; direction=u parentid=O43524; parentsymbol=FOXO3; site=APRRRAVsMDNSNkY; position=ser253; sitegrpid=449108; ptm=p; direction=d parentid=O43524; parentsymbol=FOXO3; site=QsRPRsCtWPLQRPE; position=tyr32; sitegrpid=448602; ptm=p; direction=d parentid=Q92934; parentsymbol=BAD; site=EIRsRHssyPAGtED; position=ser75; sitegrpid=447860; ptm=p; direction=d parentid=P55211; parentsymbol=CASP9; site=kLRRRFssLHFMVEV; position=ser196; sitegrpid=448454; ptm=p; direction=d parentid=P35222; parentsymbol=CTNNB1; site=QQQsyLDsGIHsGAT; position=ser33; sitegrpid=447487; ptm=p; direction=d amplification ce2 amplification ce2 ce2 bfd ce2 ce2 ce2 endometrial cancer pathway PW:0000611 Pathway Ontology disease pathway PW:0000013 Pathway Ontology 25514926 PubMed PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res 2015 Hornbeck PV Zhang B Murray B Kornhauser JM Latham V Skrzypek E 24576030 PubMed HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges. Arch Pathol Lab Med 2014 Buza N Roque DM Santin AD 1722028 PubMed Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Nature 1991 Hipskind RA Rao VN Mueller CG Reddy ES Nordheim A cancer pathway PW:0000605 Pathway Ontology epithelial cell of uterus CL:0002149 Cell Type endometrial cancer DOID:1380 Disease 28041631 PubMed Targeting fibroblast growth factor pathways in endometrial cancer. Curr Probl Cancer 2017 Winterhoff B Konecny GE