The Ebola virus (EBOV) pathway represents the virus infection on humans, depicted from the left to the right of the picture. The initial targets are macrophages and dendritic cells, but the virus has tropism to infect all kinds of cells, with the exception of lymphocytes. Here we represent all cells in general within one diagram.
Ebola attaches to the plasma membrane and after that, a viral glycoprotein induces penetration by endocytosis. This process is made by membrane proteins. During the penetration, its particles travel in compartments where viral glycoproteins are cleaved and fused to the endosomal membrane, which results in the uncoating of viral particles into the cell's cytoplasm. The virus then begins replicating and down-regulating the host's immune response. During the release process, the newly-created viruses are released from host cells, either by causing them to break apart, by waiting for their death, or by budding off through their membrane. Depending on the type of infected cell some trans-infection could happen.
This pathway was built using a text-mining approach to obtain interactions between genes related to this process. To our knowledge, it is the first comprehensive pathway depicting the Ebola pathway to date.a30"In humans, the HLAs corresponding to MHC class I are HLA-A, HLA-B, and HLA-C." https://en.wikipedia.org/wiki/MHC_class_I"In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR." https://en.wikipedia.org/wiki/MHC_class_IIPUBMEDba2Annotated according to synonimic name with RFC1 according to Uniprot (although not mentioned for Homo sapiens species)."Mutational analysis demonstrates that VP35 interaction is required for the functional effects of LC8."b97eadb9efdbf74e99fdbf69ef4c81fe5d1cd9ceadcebd1cd26f8ec9ac9ac9ac9ab10b51cebc79b51d1ea72c92c92f7bc9ac9ae99fe5e99e99ceeb0af97f97fd3fd3fd3fd3f68f68bddbddc92f33f33f33c81eadeadeadd51d51c79c81b4c"binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis."b97d51a64df5c4ad90fe5a57Type your comment hereviral infectious diseaseDOID:934Human Disease OntologyEbola hemorrhagic feverDOID:4325Human Disease Ontology24473128PubMedComprehensive functional analysis of N-linked glycans on Ebola virus GP1.MBio2014Lennemann NJRhein BANdungo EChandran KQiu XMaury W16140752PubMedRab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.J Virol2005Murray JLMavrakis MMcDonald NJYilla MSheng JBellini WJZhao LLe Doux JMShaw MWLuo CCLippincott-Schwartz JSanchez ARubin DHHodge TW25741013PubMedEbola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.J Virol2015Luthra PJordan DSLeung DWAmarasinghe GKBasler CF25396298PubMedImmune evasion in ebolavirus infections.Viral Immunol2015Audet JKobinger GP17339424PubMedThe DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.Blood2007Dominguez-Soto AAragoneses-Fenoll LMartin-Gayo EMartinez-Prats LColmenares MNaranjo-Gomez MBorras FEMunoz PZubiaur MToribio MLDelgado RCorbi AL26246577PubMedSuppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection.J Virol2015Okumura ARasmussen ALHalfmann PFeldmann FYoshimura AFeldmann HKawaoka YHarty RNKatze MG19694547PubMedEvasion of interferon responses by Ebola and Marburg viruses.J Interferon Cytokine Res2009Basler CFAmarasinghe GK17005688PubMedTyro3 family-mediated cell entry of Ebola and Marburg viruses.J Virol2006Shimojima MTakada AEbihara HNeumann GFujioka KIrimura TJones SFeldmann HKawaoka Y16698996PubMedEbola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation.J Virol2006Reid SPLeung LWHartman ALMartinez OShaw MLCarbonnelle CVolchkov VENichol STBasler CF26468524PubMedEbolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes.J Virol2016Simmons JAD'Souza RSRuas MGalione ACasanova JEWhite JM18769720PubMedPhosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus2008Saeed MFKolokoltsov AAFreiberg ANHolbrook MRDavey RA23573288PubMedLectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors.PLoS One2013Brudner MKarpel MLear CChen LYantosca LMScully CSarraju ASokolovska AZariffard MREisen DPMungall BAKotton DNOmari AHuang ICFarzan MTakahashi KStuart LStahl GLEzekowitz ABSpear GTOlinger GGSchmidt EVMichelow IC25493356PubMedEbola virus infection induces irregular dendritic cell gene expression.Viral Immunol2015Melanson VRKalina WVWilliams P19153231PubMedEbola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.J Virol2009Prins KCCardenas WBBasler CF22031933PubMedCathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change.J Virol2012Brecher MSchornberg KLDelos SEFusco MLSaphire EOWhite JM11017109PubMedDC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.Nat Immunol2000Geijtenbeek TBKrooshoop DJBleijs DAvan Vliet SJvan Duijnhoven GCGrabovsky VAlon RFigdor CGvan Kooyk Y25642836PubMedHuman lectins and their roles in viral infections.Molecules2015Mason CPTarr AW26379663PubMedTargeting C-Type Lectin Receptors for Cancer Immunity.Front Immunol2015Yan HKamiya TSuabjakyong PTsuji NM17718913PubMedNew insights about host response to smallpox using microarray data.BMC Syst Biol2007Esteves GHSimoes ACSouza EDias RAOspina RVenancio TM26771495PubMedEbola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.Cell2016Wang HShi YSong JQi JLu GYan JGao GF23342373PubMedEndocytic pathways involved in filovirus entry: advances, implications and future directions.Viruses2012Bhattacharyya SMulherkar NChandran K26861015PubMedDirect Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway.MBio2016Spence JSKrause TBMittler EJangra RKChandran K22383882PubMedThe ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.PLoS Pathog2012Zhang APBornholdt ZALiu TAbelson DMLee DELi SWoods VL JrSaphire EO14673115PubMedIn vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.Proc Natl Acad Sci U S A2003Panchal RGRuthel GKenny TAKallstrom GHLane DBadie SSLi LBavari SAman MJ23637409PubMedHost IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.J Virol2013Lu JQu YLiu YJambusaria RHan ZRuthel GFreedman BDHarty RN23555248PubMedTIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.PLoS Pathog2013Jemielity SWang JJChan YKAhmed AALi WMonahan SBu XFarzan MFreeman GJUmetsu DTDekruyff RHChoe H26516900PubMedRequirements within the Ebola Viral Glycoprotein for Tetherin Antagonism.Viruses2015Vande Burgt NHKaletsky RLBates P19625394PubMedRho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.J Virol2009Quinn KBrindley MAWeller MLKaludov NKondratowicz AHunt CLSinn PLMcCray PB JrStein CSDavidson BLFlick RMandell RStaplin WMaury WChiorini JA24478428PubMedRole of phosphatidylserine receptors in enveloped virus infection.J Virol2014Morizono KChen IS23870315PubMedMutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.Cell Host Microbe2013Luthra PRamanan PMire CEWeisend CTsuda YYen BLiu GLeung DWGeisbert TWEbihara HAmarasinghe GKBasler CF17065211PubMedThe VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.J Virol2007Feng ZCerveny MYan ZHe B21855102PubMedDifferential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions.Virology2011Bhattacharyya SHope TJYoung JA10975523PubMedDevelopmental control of endocytosis in dendritic cells by Cdc42.Cell2000Garrett WSChen LMKroschewski REbersold MTurley STrombetta SGalan JEMellman I.15103332PubMedEctodomain shedding of the glycoprotein GP of Ebola virus.EMBO J2004Dolnik OVolchkova VGarten WCarbonnelle CBecker SKahnt JStroher UKlenk HDVolchkov V26487564PubMedTIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.Protein Cell2015Yuan SCao LLing HDang MSun YZhang XChen YZhang LSu DWang XRao Z25136083PubMedTIM-family proteins inhibit HIV-1 release.Proc Natl Acad Sci U S A2014Li MAblan SDMiao CZheng YMFuller MSRennert PDMaury WJohnson MCFreed EOLiu SL21866103PubMedEbola virus entry requires the cholesterol transporter Niemann-Pick C1.Nature2011Carette JERaaben MWong ACHerbert ASObernosterer GMulherkar NKuehne AIKranzusch PJGriffin AMRuthel GDal Cin PDye JMWhelan SPChandran KBrummelkamp TR16051304PubMedLSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus.Virology2005Gramberg THofmann HMoller PLalor PFMarzi AGeier MKrumbiegel MWinkler TKirchhoff FAdams DHBecker SMunch JPohlmann S11461707PubMedFolate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses.Cell2001Chan SYEmpig CJWelte FJSpeck RFSchmaljohn AKreisberg JFGoldsmith MA