This pathway visualises the conversion of methionine to inorganic sulphates (involving the formation of homocysteine, a toxic intermediate also related to MTHFR deficiency [https://www.wikipathways.org/index.php/Pathway:WP4288]). Methionine, an essential amino acid, is taken in from diet and can be created from breaking down proteins.
This pathway was inspired by Chapter 3 of the book of Blau (ISBN 3642403360 (978-3642403361)).c47aka Adenosine kinasecysteine sulphinate alpha-oxoglutarate aminotransferaseNot available in Uniprot (yet) 2021-01-17S-adenosylmethionine-dependent
transmethylation enzymesCysteine dioxygenase type 1Cysteine sulfinic acid decarboxylaseSulfite oxidasehypothaurine:NAD+ oxidoreductaseTwo known cofactors: heme,Molybdenum"This vitamer is one of two active coenzymes used by vitamin B12-dependent enzymes and is the specific vitamin B12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase" https://en.wikipedia.org/wiki/Methylcobalamin5-methyltetrahydrofolate-homocysteine methyltransferaseaka Betaine--homocysteine
S-methyltransferase 1S-adenosylhomocysteine hydrolaseaka 3-sulfino-L-alaninecystathioniune beta-synthase"This vitamer is one of two active coenzymes used by vitamin B12-dependent enzymes and is the specific vitamin B12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase" https://en.wikipedia.org/wiki/Methylcobalamin5-methyltetrahydrofolate-homocysteine methyltransferasecystathioniune gamma-lyaseNot available in Rhea (yet) 2021-01-17f2bS-adenosylmethionine-dependent
transmethylation reactionseachypermethioninemia due to adenosine kinase deficiencyDOID:0111038DiseasehomocystinuriaDOID:9263Diseasecystathioninuria pathwayPW:0002561Pathway Ontologyhypermethioninemia with deficiency of S-adenosylhomocysteine hydrolaseDOID:0111039DiseasehypermethioninemiaDOID:0050544Disease6822523PubMedCysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate.J Biol Chem1983Griffith OW9783642403361ISBNPhysician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic DiseasesSpringer-Verlag Berlin Heidelberg20149783642403361PubMedPhysician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic DiseasesSpringer-Verlag Berlin Heidelberg Ed.42014Nenad BlauMarinus Duran KMichael GibsonCarlo Dionisi-Vicihypermethioninemia pathwayPW:0001868Pathway Ontologyglycine N-methyltransferase deficiency pathwayPW:0002299Pathway Ontologycysteine and methionine metabolic pathwayPW:0001078Pathway Ontology16435220PubMedMethionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases.J Inherit Metab Dis2005Linnebank MLagler FMuntau ACRöschinger WOlgemöller BFowler BKoch HGglycine N-methyltransferase deficiencyDOID:0111037DiseasecystathioninuriaDOID:0090142Diseasedisease pathwayPW:0000013Pathway Ontologyhomocystinuria pathwayPW:0001841Pathway Ontologysulfite oxidase deficiency pathwayPW:0001647Pathway Ontologyaltered metal homeostasis pathwayPW:0001832Pathway Ontologymethionine degradation pathwayPW:0001302Pathway Ontologyisolated sulfite oxidase deficiencyDOID:0111270Diseasehypermethioninemia pathwayPW:0002471Pathway Ontology