Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis. Cellular immune miRNAs target important components of the NF-κB signaling pathway at different levels regulating the inflammatory response in the pathogenesis of sepsis. Lower part of the figure illustrates the pathophysiological events in sepsis that lead to tissue injury and subsequent multiple organs failure.fa4IkB Not SpecifiedIkB Not Specified27740627PubMedCellular and viral microRNAs in sepsis: mechanisms of action and clinical applications.Cell Death Differ2016Giza DEFuentes-Mattei EBullock MDTudor SGoblirsch MJFabbri MLupu FYeung SJVasilescu CCalin GAnuclear factor kappa B signaling pathwayPW:0000499Pathway Ontologyimmune response pathwayPW:0000023Pathway Ontology