This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349].
This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes.
Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
a24
a16
AKA Peroxisome proliferator-activated receptor delta
a16
e86
d75
AKA COX-1
AKA COX-2
a16
a16
d75
d75
a16
e86
a16
e86
a16
d75
a16
a16
AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor]
a16
AKA Peroxisome proliferator-activated receptor gamma
a16
AKA Prxl2b
a16
AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor]
a16
AKA Peroxisome proliferator-activated receptor gamma
a16
AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor]
a16
AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor]
a16
AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor]
a16
e86
e86
e86
e86
e86
e86
a16
a16
d75
a16
a16
e86
e86
d0c
d0c
a16
d75
a16
d75
a16
a16
a16
a16
a16
a16
a16
a16
e86
e86
e86
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
20923771
PubMed
A mouse macrophage lipidome.
J Biol Chem
2010
Dennis EA
Deems RA
Harkewicz R
Quehenberger O
Brown HA
Milne SB
Myers DS
Glass CK
Hardiman G
Reichart D
Merrill AH Jr
Sullards MC
Wang E
Murphy RC
Raetz CR
Garrett TA
Guan Z
Ryan AC
Russell DW
McDonald JG
Thompson BM
Shaw WA
Sud M
Zhao Y
Gupta S
Maurya MR
Fahy E
Subramaniam S
cyclooxygenase mediated pathway of arachidonic acid metabolism
PW:0000461
Pathway Ontology
18761324
PubMed
New aspects of the role of hydroxyeicosatetraenoicacids in cell growth and cancer development.
Biochem Pharmacol
2009
Moreno JJ
inflammatory response pathway
PW:0000024
Pathway Ontology
234423
PubMed
Metabolism of prostaglandins E, A, and C in serum.
J Biol Chem
1975
Polet H
Levine L
arachidonic acid metabolic pathway
PW:0000460
Pathway Ontology
eicosanoid metabolic pathway
PW:0000485
Pathway Ontology
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma
PW:0001147
Pathway Ontology
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
eicosanoid signaling pathway
PW:0000565
Pathway Ontology
eicosanoid biosynthetic pathway
PW:0001239
Pathway Ontology
eicosanoid biosynthetic pathway
PW:0001239
Pathway Ontology