This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps]. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the second route, via LOX. b6e AKA Ltb4dh AKA Zadh1 AKA Ltb4dh AKA Zadh1 EC:3.4.19.14 EC:3.3.2.6 EC:1.13.11.33 EC:1.13.11.34 EC:1.14.14.94 EC:1.13.11.33 EC:1.1.1.232 b63 EC:1.11.1.9 EC:3.3.2.6 EC:1.3.1.48 b63 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC 19244215 PubMed Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res 2009 Buczynski MW Dumlao DS Dennis EA 18761324 PubMed New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol 2009 Moreno JJ eicosanoid metabolic pathway PW:0000485 Pathway Ontology 6321468 PubMed Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem 1984 Lee TH Menica-Huerta JM Shih C Corey EJ Lewis RA Austen KF lipoxygenase mediated pathway of arachidonic acid metabolism PW:0000462 Pathway Ontology