This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps].
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349].
This pathway visualises the second route, via LOX.
b6e
AKA Ltb4dh
AKA Zadh1
AKA Ltb4dh
AKA Zadh1
EC:3.4.19.14
EC:3.3.2.6
EC:1.13.11.33
EC:1.13.11.34
EC:1.14.14.94
EC:1.13.11.33
EC:1.1.1.232
b63
EC:1.11.1.9
EC:3.3.2.6
EC:1.3.1.48
b63
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
19244215
PubMed
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.
J Lipid Res
2009
Buczynski MW
Dumlao DS
Dennis EA
18761324
PubMed
New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.
Biochem Pharmacol
2009
Moreno JJ
eicosanoid metabolic pathway
PW:0000485
Pathway Ontology
6321468
PubMed
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.
J Biol Chem
1984
Lee TH
Menica-Huerta JM
Shih C
Corey EJ
Lewis RA
Austen KF
lipoxygenase mediated pathway of arachidonic acid metabolism
PW:0000462
Pathway Ontology