This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349].
This pathway visualises the third route, via CYP.
Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
cb4
AKA Peroxisome proliferator-activated receptor gamma
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AKA Peroxisome proliferator-activated receptor alpha
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26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
20923771
PubMed
A mouse macrophage lipidome.
J Biol Chem
2010
Dennis EA
Deems RA
Harkewicz R
Quehenberger O
Brown HA
Milne SB
Myers DS
Glass CK
Hardiman G
Reichart D
Merrill AH Jr
Sullards MC
Wang E
Murphy RC
Raetz CR
Garrett TA
Guan Z
Ryan AC
Russell DW
McDonald JG
Thompson BM
Shaw WA
Sud M
Zhao Y
Gupta S
Maurya MR
Fahy E
Subramaniam S
eicosanoid metabolic pathway
PW:0000485
Pathway Ontology
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma
PW:0001147
Pathway Ontology
cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism
PW:0000463
Pathway Ontology