This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids. cb4 AKA Peroxisome proliferator-activated receptor gamma eae eae eae eae eae eae eae eae eae eae AKA Peroxisome proliferator-activated receptor alpha eae eae eae eae eae 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S eicosanoid metabolic pathway PW:0000485 Pathway Ontology eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma PW:0001147 Pathway Ontology cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism PW:0000463 Pathway Ontology