This pathway is inspired by the [LIPID MAPS Eicosanoids Pathway expended pathway display](https://lipidmaps.org/pathway/pathways_maps) and extended with the bottom left side of Figure 1 from [Dennis and Norris 2015](https://www.ncbi.nlm.nih.gov/pubmed/26139350). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) [WP4347](https://www.wikipathways.org/index.php/Pathway:WP4347), lipooxygenases(LOX) [WP4348](https://www.wikipathways.org/index.php/Pathway:WP4348), or cytochrome P450 monooxygenases (CYP) [WP4349](https://www.wikipathways.org/index.php/Pathway:WP4349). This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids. cb4 AKA Peroxisome proliferator-activated receptor gamma eae eae eae eae eae eae eae eae eae eae AKA Peroxisome proliferator-activated receptor alpha eae eae eae eae eae cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism PW:0000463 Pathway Ontology eicosanoid metabolic pathway PW:0000485 Pathway Ontology 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma PW:0001147 Pathway Ontology 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC