Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.e1cno idea what that should beno annotation found yetno annotation found yetno annotation found yet27173435PubMedAn organelle-specific protein landscape identifies novel diseases and molecular mechanisms.Nat Commun2016Boldt Kvan Reeuwijk JLu QKoutroumpas KNguyen TMTexier Yvan Beersum SEHorn NWiller JRMans DADougherty GLamers IJCoene KLArts HHBetts MJBeyer TBolat EGloeckner CJHaidari KHetterschijt LIaconis DJenkins DKlose FKnapp BLatour BLetteboer SJMarcelis CLMitic DMorleo MOud MMRiemersma MRix STerhal PAToedt Gvan Dam TJde Vrieze EWissinger YWu KMApic GBeales PLBlacque OEGibson TJHuynen MAKatsanis NKremer HOmran Hvan Wijk EWolfrum UKepes FDavis EEFranco BGiles RHUeffing MRussell RBRoepman RMeckel syndromeDOID:0050778DiseaseciliopathyDOID:0060340DiseaseBardet-Biedl syndromeDOID:1935Diseasetransport pathwayPW:0000103Pathway Ontologypolycystic kidney diseaseDOID:0080322DiseaseUsher syndromeDOID:0050439Disease