Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory potential. e40 cd1 altered regulatory pathway PW:0000263 Pathway Ontology disease by infectious agent DOID:0050117 Human Disease Ontology 19740705 PubMed The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol 2009 Filková M Haluzík M Gay S Senolt L 17072321 PubMed Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 2006 Gilmore TD