Selective expression of chemokine receptors during T-cell polarization. Pathway based on Biocarta pathway (M4047). https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway The polarization of T cells into Th1 and Th2 cells is associated with their expression of subsets of chemokine receptors. While not being exposed to antigens, naïve T cells express CXCR4 and CCR7 receptors. TGF-beta van induce semi-naive T cells, that express a subset of CCR4 and CCR7 receptors. Th1 express CXCR3, CCR1, CCR2 and CCR5 receptors, while Th2 express CCR2, CCR3 and CCR5. However these subsets are not absolute as there is overlap between the expression of receptor subsets and thus between Th1 and Th2 cells. dfe T-helper 1 cell CL:0000545 Cell Type T cell CL:0000084 Cell Type chemokine mediated signaling pathway PW:0000829 Pathway Ontology dendritic cell CL:0000451 Cell Type T-helper 2 cell CL:0000546 Cell Type macrophage CL:0000235 Cell Type 15609003 PubMed Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol 2005 de Jong EC Smits HH Kapsenberg ML