Selective expression of chemokine receptors during T-cell polarization.
Pathway based on Biocarta pathway (M4047).
https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway
The polarization of T cells into Th1 and Th2 cells is associated with their expression of subsets of chemokine receptors. While not being exposed to antigens, naïve T cells express CXCR4 and CCR7 receptors. TGF-beta van induce semi-naive T cells, that express a subset of CCR4 and CCR7 receptors. Th1 express CXCR3, CCR1, CCR2 and CCR5 receptors, while Th2 express CCR2, CCR3 and CCR5. However these subsets are not absolute as there is overlap between the expression of receptor subsets and thus between Th1 and Th2 cells. dfeT-helper 1 cellCL:0000545Cell TypeT cellCL:0000084Cell Typechemokine mediated signaling pathwayPW:0000829Pathway Ontologydendritic cellCL:0000451Cell TypeT-helper 2 cellCL:0000546Cell TypemacrophageCL:0000235Cell Type15609003PubMedDendritic cell-mediated T cell polarization.Springer Semin Immunopathol2005de Jong ECSmits HHKapsenberg ML